Lot numbers can be found on the outside label of a product:
tert-Butyl 3-aminoazetidine-1-carboxylate
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CAS No. 193269-78-2
- Cat. No. CS-W009078
- Purity≥98%
- MDL No.MFCD01861753
*For research and further manufacturing use only, not for direct human use.
Structure of 193269-78-2
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General Information
- CAS No. 193269-78-2
- Cat. No. CS-W009078
- Purity ≥98%
- MDL No. MFCD01861753
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₁₆N₂O₂
- Molecular Weight 172.22
- Synonym(s) N-Boc-3-amino-azetidine
- SMILES O=C(OC(C)(C)C)N1CC(N)C1
Description
tert-Butyl 3-aminoazetidine-1-carboxylate features a strained azetidine ring bearing a primary amine and a tert-butyl ester, enabling direct incorporation into peptide-like scaffolds. The protected amine facilitates selective derivatization, while the bicyclic core imparts conformational rigidity beneficial in bioactive molecule design.
Application
tert-Butyl 3-aminoazetidine-1-carboxylate serves as a versatile scaffold for the synthesis of azetidine-containing bioactive molecules. The protected amine and carboxylate groups enable orthogonal functionalization, while the strained four-membered ring imparts unique conformational rigidity. It facilitates efficient access to medicinally relevant azetidine derivatives via standard coupling, reduction, and cyclization protocols, offering excellent bench stability and ease of purification in multi-step syntheses.
Synthesis
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Route1
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429672-02-6 - ~99%
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In-stock
193269-78-2
References
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WO2004/74283 A1, ; Page 40 ; WO 2004/074283 A1
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Route2
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In-stock
141699-55-0 - ~%
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In-stock
193269-78-2
References
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US2011/166121 A1, ; US 20110166121 A1
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Route3
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In-stock
24424-99-5 - ~%
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In-stock
193269-78-2
References
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US2011/166121 A1, ; US 20110166121 A1
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 2735
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H314-H318
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 55.56
- LogP 0.5644
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
- 193269-78-2 sigma193269-78-2 manufacturer193269-78-2 price193269-78-2 structure193269-78-2 SDSbuy 193269-78-2193269-78-2 supplier193269-78-2 uses193269-78-2 molecular weightprice of 193269-78-2193269-78-2 chemical name formula of 193269-78-2