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Isoquinolin-1-ylmethanamine;dihydrochloride

  • CAS No. 19382-38-8

  • Cat. No. CS-0060585
  • Molecule weight231.12
  • Purity≥97%
  • MDL No.MFCD06796244

*For research and further manufacturing use only, not for direct human use.

Isoquinolin-1-ylmethanamine;dihydrochloride|CS-0060585

Structure of 19382-38-8

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General Information

  • CAS No. 19382-38-8
  • Cat. No. CS-0060585
  • Purity ≥97%
  • MDL No. MFCD06796244
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂Cl₂N₂
  • Molecular Weight 231.12
  • Synonym(s) 1-Isoquinolin-1-ylmethanamine dihydrochloride
  • SMILES NCC1=NC=CC2=CC=CC=C21.Cl.Cl

Description

Isoquinolin-1-ylmethanamine; dihydrochloride delivers a bench-stable, moisture-tolerant scaffold for medicinal chemistry. This nitrogen-rich heterocycle integrates readily into bioactive molecules, offering enhanced solubility and favorable binding interactions in target-directed synthesis.

Application

Isoquinolin-1-ylmethanamine dihydrochloride serves as a versatile building block for medicinal chemistry and catalytic synthesis, enabling efficient construction of isoquinoline-based scaffolds. Its well-defined amine functionality facilitates straightforward derivatization, while the dihydrochloride salt enhances solubility and stability in aqueous and polar organic media. This compound functions reliably in coupling reactions, reductive amination protocols, and heterocycle functionalization, offering consistent performance in high-throughput screening and process-scale applications.

Synthesis

  • Route1
    • null|null
      113883-31-1
    • ~73%
    • In-stock
      Isoquinolin-1-ylmethanamine;dihydrochloride|CS-0060585
      19382-38-8

    References

    • Yousif, M. Mohammed; Saeki, S.; Hamana, M. Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 1029 - 1034

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.5371
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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