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Structure of 1978-38-7
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N-Methyl-2-fluoroaniline features a fluorinated aromatic ring paired with a methylamino substituent, delivering enhanced electron density at the para-position. This combination enables efficient coupling reactions in pharmaceutical synthesis and facilitates selective functionalization under mild conditions. The molecule exhibits good stability and solubility in common organic solvents, simplifying handling in multi-step transformations.
N-Methyl-2-fluoroaniline serves as a versatile building block in medicinal chemistry, enabling direct incorporation of fluorinated aromatic amine motifs into drug candidates. Its ortho-fluorine substituent enhances metabolic stability and modulates electronic properties, while the N-methyl group improves lipophilicity and membrane permeability. The compound exhibits good bench stability and reacts predictably in standard coupling, electrophilic substitution, and reductive amination protocols, facilitating efficient synthesis of complex heterocyclic scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: