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N-Methyl-1-(pyridin-2-yl)methanamine

  • CAS No. 21035-59-6

  • Cat. No. CS-0038433
  • Purity≥98%
  • MDL No.MFCD02089407

*For research and further manufacturing use only, not for direct human use.

N-Methyl-1-(pyridin-2-yl)methanamine|CS-0038433

Structure of 21035-59-6

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General Information

  • CAS No. 21035-59-6
  • Cat. No. CS-0038433
  • Purity ≥98%
  • MDL No. MFCD02089407
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀N₂
  • Molecular Weight None
  • Synonym(s) 2-Pyridinemethanamine, N-methyl-
  • SMILES CNCC1=NC=CC=C1

Description

N-Methyl-1-(pyridin-2-yl)methanamine features a pyridine ring directly attached to a methylene bridge, bearing a methylated amine group. This configuration imparts enhanced lipophilicity and improved metabolic stability compared to its unsubstituted analog. The compound serves as a key building block in the synthesis of bioactive heterocycles and ligands for transition metal catalysis.

Application

N-Methyl-1-(pyridin-2-yl)methanamine serves as a versatile building block in medicinal chemistry, enabling the construction of pyridine-containing scaffolds via standard coupling and functionalization reactions. Its amine functionality exhibits favorable reactivity in amidation, alkylation, and electrophilic substitution processes, while the pyridine ring provides orthogonal handling for further derivatization. The compound demonstrates bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns and API intermediate development.

Synthesis

  • Route1

    References

    • LUCKY LTD. Patent: EP601486 A1, 1994 ;
  • Route2
    • In-stock
      2-(Chloromethyl)pyridine hydrochloride|CS-W007502
      6959-47-3
    • null|null
      74-89-5
    • ~68%
    • In-stock
      N-Methyl-1-(pyridin-2-yl)methanamine|CS-0038433
      21035-59-6

    References

    • Zara-Kaczian, Erzsebet; Deak, Gyula; Gyoergy, Lajos Acta Chimica Hungarica, 1989 , vol. 126, # 4 p. 441 - 454
  • Route3
    • null|null
      7032-20-4
    • ~49%
    • In-stock
      N-Methyl-1-(pyridin-2-yl)methanamine|CS-0038433
      21035-59-6
    • null|null
      118792-79-3
    • null|null
      118792-78-2

    References

    • Mangeney, P.; Tejero, T.; Alexakis, A.; Grosjean, F.; Normant, J. Synthesis, 1988 , # 3 p. 255 - 257

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅱ
Hazard Statements : H227-H314-H302
Precautionary Statements : P210-P260-P264-P270-P280-P301+P310-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P363-P370+P378-P403+P235-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   24.92
  • LogP   0.801
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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