Mal-PEG4-Val-Cit-PAB-PNP

Name: Mal-PEG4-Val-Cit-PAB-PNP
Brand: ChemScene
Availability: InStock
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CAS No. 2112738-09-5
Cat. No. CS-0114403
Purity≥98%
MDL No.MFCD30828694

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

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Structure of 2112738-09-5

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Description

Mal-PEG4-Val-Cit-PAB-PNP features a maleimide warhead for selective bioconjugation, linked via a PEG4 spacer to a Val-Cit dipeptide cleavable by cathepsin B. The PAB-PNP moiety enables efficient linker release in target cells, supporting stable antibody-drug conjugate assembly and controlled payload delivery.

Application

Mal-PEG4-Val-Cit-PAB-PNP serves as a robust, hydrolytically stable linker for antibody-drug conjugates, enabling site-specific payload attachment via maleimide-thiol chemistry. The PEG4 spacer enhances solubility and reduces aggregation, while the Val-Cit dipeptide provides cleavability by cathepsin B in lysosomal environments. The PAB-PNP moiety facilitates efficient drug release, making this linker ideal for constructing homogeneous, potent ADCs with improved pharmacokinetic profiles.

General Information

CAS No. 2112738-09-5
Cat. No. CS-0114403
Purity ≥98%
MDL No. MFCD30828694
Storage -20°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄₀H₅₃N₇O₁₅
Molecular Weight 871.89
Synonym(s) None
SMILES CC(C)[C@@H](C(N[C@H](C(NC1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1)=O)CCCNC(N)=O)=O)NC(CCOCCOCCOCCOCCN3C(C=CC3=O)=O)=O

Computational Chemistry Data

TPSA 295.39
LogP 1.7045
H_Acceptors 15
H_Donors 5
Rotatable_Bonds 29

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Other Classifications

Life Science Linker Cleavable Linkers

Life Science Linker Maleimide Linkers

Life Science ADC Related Compound Cleavable Linker

Life Science ADC Related Compound Peptide/Protease Linker

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Chemical Biology PEGylation Monofunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation Heterobifunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Biochemicals and Reagents Bioconjugation Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Key Words

Mal-PEG4-Val-Cit-PAB-PNP sigmaMal-PEG4-Val-Cit-PAB-PNP manufacturerMal-PEG4-Val-Cit-PAB-PNP priceMal-PEG4-Val-Cit-PAB-PNP structureMal-PEG4-Val-Cit-PAB-PNP SDSbuy Mal-PEG4-Val-Cit-PAB-PNPMal-PEG4-Val-Cit-PAB-PNP supplierMal-PEG4-Val-Cit-PAB-PNP usesMal-PEG4-Val-Cit-PAB-PNP molecular weightprice of Mal-PEG4-Val-Cit-PAB-PNPMal-PEG4-Val-Cit-PAB-PNP chemical name formula of Mal-PEG4-Val-Cit-PAB-PNP

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Mal-PEG4-Val-Cit-PAB-PNP

CAS No. 2112738-09-5

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