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Structure of 212755-76-5
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Methyl 3-oxo-3-(4-(trifluoromethyl)phenyl)propanoate features a sterically accessible β-keto ester motif flanked by an electron-deficient aryl group, enabling direct functionalization in cross-coupling and condensation reactions. The trifluoromethyl substituent enhances metabolic stability and lipophilicity, making this scaffold valuable for medicinal chemistry and materials synthesis under standard conditions.
Methyl 3-oxo-3-(4-(trifluoromethyl)phenyl)propanoate serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of substituted cyclohexanones and heterocyclic scaffolds. Its α,β-unsaturated ketone functionality facilitates Michael additions, aldol condensations, and palladium-catalyzed couplings. The trifluoromethyl group enhances metabolic stability and lipophilicity, making it valuable in medicinal chemistry campaigns. Bench-stable and readily purified by column chromatography, it functions effectively in multi-step syntheses requiring robust functional group tolerance.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: