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CS-W001157 4
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Pomalidomide-propargyl

  • CAS No. 2154342-25-1

  • Cat. No. CS-0522481
  • Purity≥98%
  • MDL No.MFCD32063482

*For research and further manufacturing use only, not for direct human use.

Pomalidomide-propargyl|CS-0522481

Structure of 2154342-25-1

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General Information

  • CAS No. 2154342-25-1
  • Cat. No. CS-0522481
  • Purity ≥98%
  • MDL No. MFCD32063482
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₁₃N₃O₄
  • Molecular Weight 311.30
  • Synonym(s) None
  • SMILES O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCC#C)=O

Description

Pomalidomide-propargyl integrates a bioactive pomalidomide core with a terminal alkyne handle, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for conjugation. This functionalized derivative facilitates site-specific labeling and probe development in chemical biology applications.

Application

Pomalidomide-propargyl serves as a versatile synthetic building block for the construction of bioactive heterocycles and targeted covalent probes. The propargyl moiety enables reliable copper-catalyzed azide-alkyne cycloaddition (CuAAC), facilitating site-specific conjugation in medicinal chemistry campaigns. Its bench-stable nature and compatibility with diverse functional groups support streamlined synthesis workflows, making it well-suited for modular library development and probe design in oncology and immunomodulatory research.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   95.58
  • LogP   -0.2164
  • H_Acceptors   7
  • H_Donors   2
  • Rotatable_Bonds   3

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