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Structure of 22245-83-6
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2-Hydroxy-3-trifluoromethyl pyridine features a strategically positioned trifluoromethyl group that enhances electron-withdrawal and metabolic stability. This fluorinated heterocycle integrates readily into bioactive scaffolds, offering improved lipophilicity and resistance to oxidative degradation in medicinal chemistry applications.
2-Hydroxy-3-trifluoromethyl pyridine serves as a versatile building block for heterocyclic synthesis, enabling direct functionalization at the C2 position via electrophilic substitution or metal-catalyzed coupling. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the phenolic hydroxyl facilitates derivatization through etherification or esterification. Its bench-stable nature and compatibility with common reaction conditions make it suitable for medicinal chemistry campaigns and API intermediate development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: