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Structure of 1214342-70-7
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5-Chloro-3-(trifluoromethyl)pyridin-2(1H)-one features a strategically positioned chloro and trifluoromethyl group on a pyridinone scaffold, delivering enhanced electrophilicity and metabolic stability. This electron-deficient heterocycle integrates readily into medicinal chemistry campaigns, serving as a key building block for kinase inhibitors and bioactive small molecules under standard conditions.
5-Chloro-3-(trifluoromethyl)pyridin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C5 position via palladium-catalyzed cross-coupling. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the pyridinone core provides a rigid, hydrogen-bond-capable scaffold suitable for targeted interactions. Bench-stable and compatible with standard purification methods, it facilitates efficient synthesis of kinase inhibitors and other bioactive heterocycles.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: