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CS-W001157 4
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2-Fluoro-5-nitrophenol

  • CAS No. 22510-08-3

  • Cat. No. CS-W005260
  • Purity≥98%
  • MDL No.MFCD09054718

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-5-nitrophenol|CS-W005260

Structure of 22510-08-3

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General Information

  • CAS No. 22510-08-3
  • Cat. No. CS-W005260
  • Purity ≥98%
  • MDL No. MFCD09054718
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄FNO₃
  • Molecular Weight 157.10
  • Synonym(s) phenol, 2-fluoro-5-nitro-
  • SMILES OC1=CC([N+]([O-])=O)=CC=C1F

Description

2-Fluoro-5-nitrophenol features a fluorine atom at the ortho position and a nitro group at the para position relative to the hydroxyl group, creating a strongly electron-deficient aromatic ring. This combination enhances reactivity in nucleophilic substitution and coupling reactions. The compound exhibits bench-stable handling characteristics and integrates readily into complex synthetic sequences requiring activated aryl building blocks.

Application

2-Fluoro-5-nitrophenol serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct functionalization at the phenolic hydroxyl group. Its electron-deficient aromatic ring enhances reactivity in nucleophilic substitution reactions, while the fluorine and nitro groups provide orthogonal handles for further derivatization. Bench-stable and readily purified by recrystallization, it functions efficiently in coupling protocols and heterocycle formation under standard conditions.

Synthesis

  • Route1

    References

    • US2010/298293 A1, ; Page/Page column 39 ; US 20100298293 A1
  • Route2

    References

    • US5658952 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS09
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H315-H317-H318-H410
Precautionary Statements : P261-P264-P270-P272-P273-P280-P302+P352-P330-P391-P501

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Computational Chemistry Data

  • TPSA   63.37
  • LogP   1.4395
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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