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CS-W001157 4
Total: USD 88.00

5-Amino-2-fluorophenol

  • CAS No. 100367-48-4

  • Cat. No. CS-0034100
  • Molecule weightNone
  • Purity≥98%
  • MDL No.MFCD13185335

*For research and further manufacturing use only, not for direct human use.

5-Amino-2-fluorophenol|CS-0034100

Structure of 100367-48-4

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General Information

  • CAS No. 100367-48-4
  • Cat. No. CS-0034100
  • Purity ≥98%
  • MDL No. MFCD13185335
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆FNO
  • Molecular Weight None
  • Synonym(s) 4-Fluoro-3-hydroxyaniline
  • SMILES OC1=CC(N)=CC=C1F

Description

5-Amino-2-fluorophenol features a fluorine atom at the ortho position relative to a hydroxyl group, creating a unique electronic profile that enhances reactivity in coupling processes. The amino group enables direct functionalization, while the phenolic moiety supports hydrogen bonding and solubility in polar solvents. This compound serves as a key building block for bioactive molecules and advanced materials, particularly in pharmaceutical intermediates and agrochemicals.

Application

5-Amino-2-fluorophenol serves as a valuable building block in the synthesis of fluorinated aromatic scaffolds, enabling direct access to substituted anilines and heterocycles. Its ortho-amino and hydroxyl groups offer complementary reactivity for coupling reactions, cyclizations, and derivatization, with demonstrated utility in medicinal chemistry and agrochemical research. The compound exhibits good bench stability and facilitates straightforward purification via recrystallization or column chromatography.

Synthesis

  • Route1

    References

    • AMBIT BIOSCIENCES CORPORATON Patent: WO2009/117080 A1, 2009 ; Location in patent: Page/Page column 171 ; WO 2009/117080 A1
  • Route2

    References

    • WO2007/45861 A1, ; Page/Page column 66-67 ; WO 2007/045861 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   1.1135
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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