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CS-W001157 4
Total: USD 88.00

2,3,4-Trifluorophenylboronic acid

  • CAS No. 226396-32-3

  • Cat. No. CS-D1005
  • Purity≥98%
  • MDL No.MFCD01863168

*For research and further manufacturing use only, not for direct human use.

2,3,4-Trifluorophenylboronic acid|CS-D1005

Structure of 226396-32-3

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General Information

  • CAS No. 226396-32-3
  • Cat. No. CS-D1005
  • Purity ≥98%
  • MDL No. MFCD01863168
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BF₃O₂
  • Molecular Weight None
  • Synonym(s) 2,3,4-Trifluorobenzeneboronic Acid (contains varying amounts of Anhydride)
  • SMILES FC1=CC=C(B(O)O)C(F)=C1F

Description

2,3,4-Trifluorophenylboronic acid features a trifluorinated aromatic ring that imparts enhanced stability and electron-deficient character, facilitating efficient cross-coupling reactions. This bench-stable reagent integrates readily into Suzuki-Miyaura protocols, enabling reliable C–C bond formation under mild conditions.

Application

2,3,4-Trifluorophenylboronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation with aryl and vinyl halides. Its trifluorinated aryl framework imparts enhanced metabolic stability and lipophilicity, making it valuable for medicinal chemistry applications. The compound exhibits good bench stability, moderate reactivity, and compatibility with diverse functional groups, facilitating straightforward purification and integration into complex molecular architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   -0.2163
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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