Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

tert-Butyl 2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate

  • CAS No. 240401-28-9

  • Cat. No. CS-0045416
  • Purity≥95%
  • MDL No.MFCD14584466

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate|CS-0045416

Structure of 240401-28-9

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 240401-28-9
  • Cat. No. CS-0045416
  • Purity ≥95%
  • MDL No. MFCD14584466
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₃NO₃
  • Molecular Weight 241.33
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CCC2(CC1)CC(O)C2

Description

tert-Butyl 2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate is a sterically shielded spirocyclic scaffold featuring a labile hydroxyl group and a protected carboxylic acid. This configuration enables direct functionalization at the nitrogen center while maintaining stability under standard bench conditions. The tert-butyl ester facilitates convenient deprotection in late-stage synthesis, streamlining access to biologically relevant azaspiroalkane architectures.

Application

tert-Butyl 2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate serves as a versatile spirocyclic scaffold for medicinal chemistry, enabling the construction of complex nitrogen-containing heterocycles. The pendant hydroxyl group offers direct handle for derivatization, while the tert-butyl ester provides stability and convenient deprotection under mild acidic conditions. Its rigid, three-dimensional architecture enhances ligand-receptor binding selectivity and metabolic stability in bioactive molecule design.

Synthesis

  • Route1

    References

    • Brown, Dean G.; Bernstein, Peter R.; Griffin, Andrew; Wesolowski, Steve; Labrecque, Denis; Tremblay, Maxime C.; Sylvester, Mark; Mauger, Russell; Edwards, Phillip D.; Throner, Scott R.; Folmer, James J.; Cacciola, Joseph; Scott, Clay; Lazor, Lois A.; Pourashraf, Mehrnaz; Santhakumar, Vijayaratnam; Potts, William M.; Sydserff, Simon; Giguere, Pascall; Levesque, Carine; Dasser, Mohammed; Groblewski, Thierry Journal of Medicinal Chemistry, 2014 , vol. 57, # 3 p. 733 - 758
  • Route2

    References

    • Brown, Dean G.; Bernstein, Peter R.; Griffin, Andrew; Wesolowski, Steve; Labrecque, Denis; Tremblay, Maxime C.; Sylvester, Mark; Mauger, Russell; Edwards, Phillip D.; Throner, Scott R.; Folmer, James J.; Cacciola, Joseph; Scott, Clay; Lazor, Lois A.; Pourashraf, Mehrnaz; Santhakumar, Vijayaratnam; Potts, William M.; Sydserff, Simon; Giguere, Pascall; Levesque, Carine; Dasser, Mohammed; Groblewski, Thierry Journal of Medicinal Chemistry, 2014 , vol. 57, # 3 p. 733 - 758
  • Route3
    • tert-Butyl 1,1-dichloro-2-oxo-7-azaspiro[3.5]nonane-7-carboxylate|CS-0037785
      396653-31-9
    • ~%
    • In-stock
      tert-Butyl 2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate|CS-0045416
      240401-28-9

    References

    • Brown, Dean G.; Bernstein, Peter R.; Griffin, Andrew; Wesolowski, Steve; Labrecque, Denis; Tremblay, Maxime C.; Sylvester, Mark; Mauger, Russell; Edwards, Phillip D.; Throner, Scott R.; Folmer, James J.; Cacciola, Joseph; Scott, Clay; Lazor, Lois A.; Pourashraf, Mehrnaz; Santhakumar, Vijayaratnam; Potts, William M.; Sydserff, Simon; Giguere, Pascall; Levesque, Carine; Dasser, Mohammed; Groblewski, Thierry Journal of Medicinal Chemistry, 2014 , vol. 57, # 3 p. 733 - 758

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   49.77
  • LogP   2.1584
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 240401-28-9 sigma240401-28-9 manufacturer240401-28-9 price240401-28-9 structure240401-28-9 SDSbuy 240401-28-9240401-28-9 supplier240401-28-9 uses240401-28-9 molecular weightprice of 240401-28-9240401-28-9 chemical name formula of 240401-28-9
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label