4-Chloro-2,5-difluoroaniline

Name: 4-Chloro-2,5-difluoroaniline
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CAS No. 2613-30-1
Cat. No. CS-0157839
Purity≥98%
MDL No.MFCD06808807

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 2613-30-1
Cat. No. CS-0157839
Purity ≥98%
MDL No. MFCD06808807
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄ClF₂N
Molecular Weight None
Synonym(s) 4-Chloro-2,5-difluorophenylamine
SMILES C1=C(C(=CC(=C1F)N)F)Cl

Description

4-Chloro-2,5-difluoroaniline features a trifunctional aromatic core with chlorine and two fluorine substituents positioned for orthogonal reactivity. This electron-deficient aniline derivative enables direct coupling in late-stage functionalization, delivering high regioselectivity in pharmaceutical intermediates. The molecule exhibits enhanced metabolic stability and solubility under standard conditions.

Application

4-Chloro-2,5-difluoroaniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling the construction of fluorinated aromatic scaffolds. Its ortho-fluoro substitution pattern facilitates directed metalation and subsequent functionalization, while the chloro group offers compatibility with palladium-catalyzed coupling reactions. The compound exhibits good bench stability and is readily purified by recrystallization, supporting its use in multi-step syntheses requiring precise regiocontrol.

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

TPSA 26.02
LogP 2.2004
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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4-Chloro-2,5-difluoroaniline

CAS No. 2613-30-1

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