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CS-W001157 4
Total: USD 88.00

Oxetan-3-yl 4-methylbenzene-1-sulfonate

  • CAS No. 26272-83-3

  • Cat. No. CS-0037430
  • Purity≥98%
  • MDL No.None
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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

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*For research and further manufacturing use only, not for direct human use.

Oxetan-3-yl 4-methylbenzene-1-sulfonate|CS-0037430

Structure of 26272-83-3

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Description

Oxetan-3-yl 4-methylbenzene-1-sulfonate is a bench-stable, moisture-tolerant oxetane derivative that enables efficient C–C bond formation via ring-opening reactions. The electron-deficient oxetane integrates readily into complex molecular architectures, while the p-tolylsulfonyl group ensures excellent leaving-group ability. This reagent streamlines late-stage functionalization in synthetic and medicinal chemistry workflows.

Application

Oxetan-3-yl 4-methylbenzene-1-sulfonate serves as a stable, bench-friendly oxetane electrophile that facilitates efficient C–O bond formation in nucleophilic substitution reactions. Its sulfonate leaving group enables reliable coupling with amines, alcohols, and thiols under mild conditions, making it a practical reagent for constructing oxetane-containing scaffolds in medicinal chemistry and process development.

General Information

  • CAS No. 26272-83-3
  • Cat. No. CS-0037430
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂O₄S
  • Molecular Weight 228.27
  • Synonym(s) p-Toluenesulfonic Acid 3-Oxetanyl Ester
  • SMILES CC1=CC=C(C=C1)S(=O)(=O)OC2COC2

Computational Chemistry Data

  • TPSA   52.6
  • LogP   1.09912
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   3

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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