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CS-W001157 4
Total: USD 88.00

Oxetan-3-ol

  • CAS No. 7748-36-9

  • Cat. No. CS-W007362
  • Purity≥95%
  • MDL No.MFCD09056790

*For research and further manufacturing use only, not for direct human use.

Oxetan-3-ol|CS-W007362

Structure of 7748-36-9

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General Information

  • CAS No. 7748-36-9
  • Cat. No. CS-W007362
  • Purity ≥95%
  • MDL No. MFCD09056790
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₆O₂
  • Molecular Weight 74.08
  • Synonym(s) 3-Hydroxyoxetane
  • SMILES OC1COC1

Description

Oxetan-3-ol delivers a strained, three-membered cyclic ether with enhanced reactivity and bench-stable handling. This oxygen-rich heterocycle integrates readily into synthetic scaffolds, enabling efficient functionalization through ring-opening transformations under mild conditions.

Application

Oxetan-3-ol serves as a versatile building block in medicinal chemistry, enabling the introduction of strained three-membered ether rings with enhanced metabolic stability. Its hydroxyl group facilitates direct functionalization or derivatization, while the oxetane ring exhibits favorable solubility and binding properties. The compound demonstrates good bench stability and compatibility with standard coupling reactions, supporting its use in constructing bioactive heterocyclic scaffolds and API intermediates.

Synthesis

  • Route1

    References

    • Bristol-Myers Squibb Company Patent: US2008/9465 A1, 2008 ; Location in patent: Page/Page column 82 ; US 20080009465 A1
  • Route2
    • 3-Chloro-2-hydroxypropyl acetate|CS-0155004
      24573-30-6
    • null|null
      109-92-2
    • null|null
      106-89-8
    • ~%
    • In-stock
      Oxetan-3-ol|CS-W007362
      7748-36-9

    References

    • US6140271 A1, ;
  • Route3
    • 3-Chloro-2-hydroxypropyl acetate|CS-0155004
      24573-30-6
    • null|null
      106-89-8
    • ~%
    • In-stock
      Oxetan-3-ol|CS-W007362
      7748-36-9

    References

    • US4395561 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅲ
Hazard Statements : H227-H302-H315-H318-H335
Precautionary Statements : P210-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P403-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   -0.6225
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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