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CS-W001157 4
Total: USD 88.00

4-(4-Bromophenyl)morpholine

  • CAS No. 30483-75-1

  • Cat. No. CS-W009360
  • Purity≥95%
  • MDL No.MFCD04112483

*For research and further manufacturing use only, not for direct human use.

4-(4-Bromophenyl)morpholine|CS-W009360

Structure of 30483-75-1

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General Information

  • CAS No. 30483-75-1
  • Cat. No. CS-W009360
  • Purity ≥95%
  • MDL No. MFCD04112483
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂BrNO
  • Molecular Weight 242.12
  • Synonym(s) N-(4-Bromophenyl)morpholine
  • SMILES BrC1=CC=C(C=C1)N1CCOCC1

Description

4-(4-Bromophenyl)morpholine is a bench-stable, electron-rich arylmorpholine derivative featuring a brominated phenyl ring directly linked to the morpholine nitrogen. This configuration enhances its utility in transition-metal-catalyzed coupling reactions and as a key building block for bioactive molecules in medicinal chemistry and materials science.

Application

4-(4-Bromophenyl)morpholine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions such as Suzuki and Stille couplings. Its brominated aryl moiety provides high reactivity in C–C bond formation, while the morpholine ring offers favorable solubility and metabolic stability. The compound exhibits bench stability and is compatible with standard purification methods, facilitating its use in the synthesis of biologically active heterocyclic scaffolds and pharmaceutical intermediates.

Synthesis

  • Route1

    References

    • Khazaei, Ardeshir; Zolfigol, Mohammad Ali; Kolvari, Eskandar; Koukabi, Nadiya; Soltani, Hamid; Bayani, Leyla Sharaf Synthetic Communications, 2010 , vol. 40, # 19 p. 2954 - 2962
  • Route2
    • null|null
      110-91-8
    • In-stock
      4-Bromoiodobenzene|CS-W008977
      589-87-7
    • ~10%
    • In-stock
      4-(4-Bromophenyl)morpholine|CS-W009360
      30483-75-1

    References

    • Sreedhar; Arundhathi; Linga Reddy; Amarnath Reddy; Lakshmi Kantam Synthesis, 2009 , # 15 art. no. P03909SS, p. 2517 - 2522
  • Route3
    • null|null
      110-91-8
    • null|null
      321970-34-7
    • ~81%
    • In-stock
      4-(4-Bromophenyl)morpholine|CS-W009360
      30483-75-1

    References

    • Anderson, Kevin W.; Mendez-Perez, Maria; Priego, Julian; Buchwald, Stephen L. Journal of Organic Chemistry, 2003 , vol. 68, # 25 p. 9563 - 9573

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   12.47
  • LogP   2.2857
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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