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CS-W001157 4
Total: USD 88.00

Tetrahydro-2H-pyran-4-amine hydrochloride

  • CAS No. 33024-60-1

  • Cat. No. CS-W002372
  • Purity≥97%
  • MDL No.MFCD00100881

*For research and further manufacturing use only, not for direct human use.

Tetrahydro-2H-pyran-4-amine hydrochloride|CS-W002372

Structure of 33024-60-1

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General Information

  • CAS No. 33024-60-1
  • Cat. No. CS-W002372
  • Purity ≥97%
  • MDL No. MFCD00100881
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₂ClNO
  • Molecular Weight 137.61
  • Synonym(s) tetrahydro-2H-pyran-4-aminium chloride
  • SMILES NC1CCOCC1.[H]Cl

Description

Phosphoric acid is used mainly in fertilizers. It is used as an external standard for phosphorus-31 Nuclear magnetic resonance (NMR); as an electrolyte in phosphoric acid fuel cells and as a catalyst in the hydration of alkenes to produce alcohols, predominantly ethanol. It finds application as a buffer agent in biology and chemistry; as a solution for anodizing and as a cleaner by construction trades to remove mineral deposits, cementitious smears and hard water stains. It is also used as a pH adjuster in cosmetics and skin-care products and a dispersing agent in detergents and leather treatment. It plays an important role in the preparation of albumin derivatives. It is an important starting material used in the preparation of disodium hydrogen phosphate, trisodium phosphate, calcium dihydrogen phosphate and monohydrogen phosphate. It is also used in dentistry and orthodontics as an etching solution as well as a sanitizing agent in dairy, food and brewing industries. It serves as an acidic fruitlike flavoring in food products. It is widely used to remove rust in steel tools or surfaces by converting the rusted ion in to water soluble phosphate compound.

Application

Tetrahydro-2H-pyran-4-amine hydrochloride serves as a versatile building block in synthetic organic chemistry, offering a readily accessible secondary amine functionality within a stable, bench-ready heterocyclic framework. Its hydrochloride salt form enhances solubility and handling, enabling efficient use in nucleophilic substitutions, reductive aminations, and peptide coupling reactions. The tetrahydropyran ring provides conformational rigidity and metabolic stability, making it valuable for constructing bioactive scaffolds in medicinal chemistry and process development.

Synthesis

  • Route1
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    • In-stock
      Tetrahydro-2H-pyran-4-amine hydrochloride|CS-W002372
      33024-60-1

    References

    • WO2004/24728 A2, ; Page 94 ; WO 2004/024728 A2
  • Route2

    References

    • EP1535922 A1, ; Page/Page column 40 ;
  • Route3

    References

    • WO2007/36791 A1, ; Page/Page column 42 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   0.5459
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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