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CS-W001157 4
Total: USD 88.00

5-(trifluoromethyl)pyridin-2-ol

  • CAS No. 33252-63-0

  • Cat. No. CS-B0101
  • Purity≥97%
  • MDL No.MFCD00042315

*For research and further manufacturing use only, not for direct human use.

5-(trifluoromethyl)pyridin-2-ol|CS-B0101

Structure of 33252-63-0

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General Information

  • CAS No. 33252-63-0
  • Cat. No. CS-B0101
  • Purity ≥97%
  • MDL No. MFCD00042315
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄F₃NO
  • Molecular Weight 163.10
  • Synonym(s) BUTTPARK 24\01-67
  • SMILES FC(F)(F)C(C=C1)=CN=C1O

Description

5-(trifluoromethyl)pyridin-2-ol features a trifluoromethyl group at the 5-position and a hydroxyl moiety at the 2-position of the pyridine ring, creating a uniquely electron-deficient heterocycle. This combination enhances its utility as a building block in medicinal chemistry, where the polar hydroxyl group facilitates hydrogen bonding and improves solubility. The molecule exhibits bench-stable behavior under standard conditions and serves as a key scaffold for bioactive compound synthesis.

Synthesis

  • Route1
    • null|null
      1163304-58-2
    • ~99%
    • In-stock
      5-(trifluoromethyl)pyridin-2-ol|CS-B0101
      33252-63-0

    References

    • Yamaguchi, Ryohei; Ikeda, Chikako; Takahashi, Yoshinori; Fujita, Ken-Ichi Journal of the American Chemical Society, 2009 , vol. 131, p. 8410 - 8412
  • Route2
    • null|null
      1448448-07-4
    • ~99%
    • In-stock
      5-(trifluoromethyl)pyridin-2-ol|CS-B0101
      33252-63-0

    References

    • Zhou, Kang; Wen, Ping; Chen, Wenlin; Ma, Chaowei; Huang, Guosheng European Journal of Organic Chemistry, 2013 , # 3 p. 448 - 452
  • Route3

    References

    • Haga, Takahiro; Fujikawa, Kan-ichi; Koyanagi, Tohru; Nakajima, Toshio; Hayashi, Kouji Heterocycles, 1984 , vol. 22, # 1 p. 117 - 124

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.806
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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