2-Chloro-6-methoxypyrazine

Name: 2-Chloro-6-methoxypyrazine
Brand: ChemScene
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CAS No. 33332-30-8
Cat. No. CS-W019039
Purity≥97%
MDL No.MFCD06410937

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 33332-30-8

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Description

2-Chloro-6-methoxypyrazine is a heterocyclic compound featuring a pyrazine core substituted with chlorine at the 2-position and a methoxy group at the 6-position. This electron-deficient framework enables selective coupling in synthetic transformations, offering enhanced stability under standard bench conditions. The molecule integrates readily into complex molecular architectures requiring defined polarity and metabolic resistance.

Application

2-Chloro-6-methoxypyrazine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to pyrazine-based scaffolds through palladium-catalyzed cross-coupling reactions. Its chlorine atom facilitates nucleophilic substitution under mild conditions, while the methoxy group enhances solubility and modulates electronic properties. The compound exhibits excellent bench stability and is compatible with standard purification protocols, making it well-suited for iterative synthesis campaigns in API development.

General Information

CAS No. 33332-30-8
Cat. No. CS-W019039
Purity ≥97%
MDL No. MFCD06410937
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₅ClN₂O
Molecular Weight 144.56
Synonym(s) 6-Methoxy-2-chloropyrazine
SMILES ClC1=NC(=CN=C1)OC

Computational Chemistry Data

TPSA 35.01
LogP 1.1386
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazine compounds

Key Words

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2-Chloro-6-methoxypyrazine

CAS No. 33332-30-8

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