2,4-Difluoroaniline

Name: 2,4-Difluoroaniline
Brand: ChemScene
Availability: InStock
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CAS No. 367-25-9
Cat. No. CS-W020027
Purity≥98%
MDL No.MFCD00007648

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

2,4-Difluoroaniline features two fluorine atoms at the 2- and 4-positions of the aniline ring, imparting enhanced electron-withdrawing character and improved metabolic stability. This ortho- and para-fluorinated scaffold integrates readily into pharmaceutical intermediates, enabling efficient coupling reactions under mild conditions. The molecule exhibits favorable solubility in common organic solvents and maintains stability during standard bench handling.

Application

2,4-Difluoroaniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct incorporation of fluorinated aromatic scaffolds. Its ortho- and para-fluorine substituents facilitate subsequent cross-coupling reactions and nucleophilic aromatic substitution, while the primary amine functions as a key handle for derivatization. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for use in multi-step synthetic sequences requiring functional group tolerance and predictable reactivity.

General Information

CAS No. 367-25-9
Cat. No. CS-W020027
Purity ≥98%
MDL No. MFCD00007648
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅F₂N
Molecular Weight None
Synonym(s) 2,4-Difluorobenzenamine; 2,4-Difluorophenylamine; NSC 10297; 2,4-Difluoro Aniline
SMILES NC1=CC=C(F)C=C1F

Computational Chemistry Data

TPSA 26.02
LogP 1.547
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2941
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H302-H311-H331
Precautionary Statements : P261-P271-P280-P302+P352-P304+P340-P311-P312-P361-P363-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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2,4-Difluoroaniline

CAS No. 367-25-9

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