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Structure of 5509-65-9
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2,6-Difluoroaniline was used in the synthesis of:N-2,6-difluorophenyl-5-methoxy-1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamide, herbicidal compoundseries of 2,6,9-trisubstituted purine inhibitors of p38 kinasesubstituted phenylthiomorpholine dioxide, an active pharmaceutical intermediate
2,6-Difluoroaniline serves as a valuable building block in medicinal chemistry and agrochemical synthesis, offering enhanced metabolic stability and improved solubility compared to unsubstituted anilines. Its ortho-fluoro substituents enable selective electrophilic substitution and facilitate coupling reactions via Pd-catalyzed cross-coupling protocols. The molecule exhibits good bench stability and is compatible with common protecting group strategies, enabling efficient access to complex heterocyclic scaffolds and functionalized aromatic systems in multi-step syntheses.
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GHS Pictogram :
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GHS No : GHS02,GHS07
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Signal Word : Warning
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UN#: 1993
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Class : 3
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Packing Group : Ⅲ
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Hazard Statements : H226
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P370+P378-P501
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Lot numbers can be found on the outside label of a product: