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Structure of 369638-69-7
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Tert-butyl (5-(bromomethyl)pyrazin-2-yl)carbamate features a bromomethyl group at the 5-position of a pyrazine ring, enabling direct functionalization in late-stage diversification. The tert-butyl carbamate handle offers stability and convenient deprotection under mild acidic conditions. This reagent integrates readily into synthetic sequences requiring selective alkylation or transition-metal-catalyzed coupling reactions.
Tert-butyl (5-(bromomethyl)pyrazin-2-yl)carbamate serves as a versatile building block for the synthesis of pyrazine-based pharmaceutical intermediates and functionalized heterocycles. The bromomethyl group enables facile Suzuki, Stille, or nucleophilic substitution reactions, while the tert-butyl carbamate protects the pyrazin-2-amine nitrogen under standard conditions. Its bench-stable nature and compatibility with diverse coupling protocols make it ideal for iterative C–H functionalization and late-stage diversification in medicinal chemistry workflows.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 3259
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H314
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Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P405-P501
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Lot numbers can be found on the outside label of a product: