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Structure of 38186-86-6
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6-Chloro-5-fluoronicotinic acid features a highly electron-deficient pyridine core, enabling efficient coupling in cross-coupling reactions. The ortho-chloro and meta-fluoro substituents provide orthogonal reactivity for selective functionalization, while the carboxylic acid group facilitates direct conjugation or derivatization under standard conditions.
6-Chloro-5-fluoronicotinic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into bioactive heterocycles via standard coupling reactions. Its ortho-halogenated pyridine core facilitates palladium-catalyzed cross-couplings and nucleophilic aromatic substitution, while the carboxylic acid group allows for facile derivatization. Bench-stable and compatible with diverse functional groups, it functions as a key scaffold for developing pharmaceutical intermediates and agrochemicals.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: