(1H-Indol-7-yl)methanamine

Name: (1H-Indol-7-yl)methanamine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 408356-52-5
Cat. No. CS-0052535
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 408356-52-5
Cat. No. CS-0052535
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₀N₂
Molecular Weight 146.19
Synonym(s) N-methyl-1H-indol-7-amine
SMILES NCC1=CC=CC2=C1NC=C2

Description

(1H-Indol-7-yl)methanamine is a bench-stable, nitrogen-rich heterocyclic amine featuring a primary amine group directly attached to the indole scaffold. This configuration enables direct incorporation into bioactive molecule synthesis, particularly in medicinal chemistry and fluorescent probe development. The compound's electron-rich indole core facilitates efficient coupling reactions under mild conditions.

Application

(1H-Indol-7-yl)methanamine serves as a versatile building block for medicinal chemistry and heterocyclic synthesis, enabling efficient access to indole-based scaffolds. Its primary amine functionality facilitates straightforward derivatization via amidation, alkylation, and reductive amination, while the indole core supports electrophilic substitution and metal-catalyzed coupling reactions. The compound exhibits good bench stability and is readily purified by standard chromatographic methods, making it well-suited for iterative synthesis workflows in API development.

Synthesis

Route1
- In-stock
  
  1074-88-0
- ~87%
- In-stock
  
  408356-52-5
References
- Engler, Thomas Albert; Furness, Kelly Wayne; Malhotra, Sushant; Briggs, Stephen Lyle; Brooks, Harold Burns; Clawson, David Keyes; Sanchez-Martinez, Concepcion; Zhang, Faming; Zhu, Guoxin Patent: US2004/48915 A1, 2004 ;
Route2
- 1108723-69-8
- ~99%
- In-stock
  
  408356-52-5
References
- COMENTIS, INC.; PURDUE RESEARCH FOUNDATION Patent: WO2009/42694 A1, 2009 ; Location in patent: Page/Page column 90-91 ; WO 2009/042694 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 41.81
LogP 1.6266
H_Acceptors 1
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Indole compounds

Key Words

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(1H-Indol-7-yl)methanamine

CAS No. 408356-52-5

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