1,4-Diformylpiperazine

Name: 1,4-Diformylpiperazine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 4164-39-0
Cat. No. CS-0155228
Purity≥98%
MDL No.MFCD00006153

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 4164-39-0

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Description

1,4-Diformylpiperazine features two aldehyde groups at opposite positions on a piperazine ring, enabling bifunctional coupling in synthetic transformations. This rigid, electron-deficient scaffold facilitates efficient conjugation in peptide derivatization and polymer functionalization under standard conditions.

Application

1,4-Diformylpiperazine serves as a versatile bifunctional building block in synthetic chemistry, enabling efficient construction of heterocyclic scaffolds and macrocyclic architectures. Its two aldehyde groups offer orthogonal reactivity for imine formation, reductive amination, or oxime coupling, facilitating the synthesis of complex molecular frameworks. The piperazine core provides enhanced solubility and metabolic stability, making it valuable in medicinal chemistry lead optimization. Bench-stable and readily purified by recrystallization, it functions reliably in standard reaction conditions across diverse synthetic workflows.

General Information

CAS No. 4164-39-0
Cat. No. CS-0155228
Purity ≥98%
MDL No. MFCD00006153
Storage -20°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₀N₂O₂
Molecular Weight 142.16
Synonym(s) piperazine-1,4-dicarbaldehyde
SMILES C1CN(CCN1C=O)C=O

Computational Chemistry Data

TPSA 40.62
LogP -1.0832
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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1,4-Diformylpiperazine

CAS No. 4164-39-0

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