2-Amino-5-cyanopyridine

Name: 2-Amino-5-cyanopyridine
Brand: ChemScene
Availability: InStock
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CAS No. 4214-73-7
Cat. No. CS-W009186
Purity≥97%
MDL No.MFCD00128902

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

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Description

2-Amino-5-cyanopyridine features a dual functionalization pattern with an amino group and a cyano moiety positioned ortho to each other on the pyridine ring. This arrangement enables efficient integration into heterocyclic architectures, particularly in medicinal chemistry scaffolds and transition metal-catalyzed coupling reactions. The molecule exhibits enhanced solubility and stability under standard conditions, facilitating its use in synthetic workflows.

Application

2-Amino-5-cyanopyridine serves as a versatile building block in heterocyclic synthesis, enabling efficient access to substituted pyridine scaffolds via nucleophilic addition and coupling reactions. Its dual functionality—amine and nitrile groups—facilitates orthogonal transformations, including amidation, cyclization, and transition-metal-catalyzed cross-couplings. The compound exhibits good bench stability and is readily purified by recrystallization, making it well-suited for scalable medicinal chemistry campaigns and API intermediate development.

General Information

CAS No. 4214-73-7
Cat. No. CS-W009186
Purity ≥97%
MDL No. MFCD00128902
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅N₃
Molecular Weight None
Synonym(s) 6-aminopyridine-3-carbonitrile
SMILES N#CC1=CC=C(N=C1)N

Computational Chemistry Data

TPSA 62.7
LogP 0.53548
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H302-H312-H314-H332
Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P310-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P304+P341-P305+P351+P338-P310-P312-P330-P363-P405-P501

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Other Classifications

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Amino-5-cyanopyridine

CAS No. 4214-73-7

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