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CS-W001157 4
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4-Bromo-2-fluoro-6-methylaniline

  • CAS No. 429683-46-5

  • Cat. No. CS-0012910
  • Purity≥98%
  • MDL No.MFCD22683228

*For research and further manufacturing use only, not for direct human use.

4-Bromo-2-fluoro-6-methylaniline|CS-0012910

Structure of 429683-46-5

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General Information

  • CAS No. 429683-46-5
  • Cat. No. CS-0012910
  • Purity ≥98%
  • MDL No. MFCD22683228
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇BrFN
  • Molecular Weight 204.04
  • Synonym(s) 4-Bromo-2-fluoro-6-methylbenzenamine
  • SMILES FC1=C(N)C(C)=CC(Br)=C1

Description

4-Bromo-2-fluoro-6-methylaniline is a fluorinated aryl amine featuring orthogonal halogen and methyl directing groups, enabling selective functionalization in cross-coupling and electrophilic substitution. This bench-stable derivative integrates readily into complex heterocyclic scaffolds under mild conditions.

Application

4-Bromo-2-fluoro-6-methylaniline serves as a valuable building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-substituted arylamine framework enables efficient coupling reactions, including Suzuki-Miyaura and Buchwald-Hartwig protocols, while the bromo and fluoro groups provide orthogonal reactivity for sequential functionalization. The methyl group enhances metabolic stability and modulates electronic properties, making this compound well-suited for medicinal chemistry campaigns requiring precise substitution patterns and robust bench stability.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.47882
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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