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Structure of 452-69-7
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4-Fluoro-3-methylaniline features a fluorinated aromatic ring paired with adjacent methyl and amino groups, delivering enhanced electron density at the para-position. This configuration supports efficient coupling reactions in pharmaceutical synthesis, where its stability under standard conditions enables reliable incorporation into complex molecular architectures.
4-Fluoro-3-methylaniline serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds via standard coupling reactions. Its ortho-methyl and meta-fluoro substituents provide directed functionalization potential and enhanced metabolic stability. The compound exhibits good bench stability, facilitates straightforward purification, and functions effectively in amide formation, Suzuki-Miyaura couplings, and heterocycle construction within established synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501
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Lot numbers can be found on the outside label of a product: