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CS-W001157 4
Total: USD 88.00

4-Pyrimidine methanamine

  • CAS No. 45588-79-2

  • Cat. No. CS-W018555
  • Purity≥97%
  • MDL No.MFCD06796202

*For research and further manufacturing use only, not for direct human use.

4-Pyrimidine methanamine|CS-W018555

Structure of 45588-79-2

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General Information

  • CAS No. 45588-79-2
  • Cat. No. CS-W018555
  • Purity ≥97%
  • MDL No. MFCD06796202
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇N₃
  • Molecular Weight 109.13
  • Synonym(s) Pyrimidin-4-ylmethanamine
  • SMILES NCC1=NC=NC=C1

Description

4-Pyrimidine methanamine delivers a reactive amine handle tethered to a heteroaromatic pyrimidine core, enabling direct incorporation into conjugation workflows. This bench-stable scaffold features enhanced solubility in aqueous and polar organic media, facilitating efficient derivatization under mild conditions.

Application

4-Pyrimidine methanamine serves as a versatile building block in medicinal chemistry, enabling the construction of pyrimidine-based heterocycles through nucleophilic substitution and condensation reactions. Its primary amine functionality offers high reactivity with electrophiles, facilitating the synthesis of targeted scaffolds. The compound exhibits bench stability, ease of purification, and compatibility with common reaction conditions, making it a practical choice for iterative synthetic campaigns in API development.

Synthesis

  • Route1
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    • ~%
    • In-stock
      4-Pyrimidine methanamine|CS-W018555
      45588-79-2

    References

    • Bulletin des Societes Chimiques Belges, , vol. 91, # 2 p. 153 - 162
  • Route2
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      1072806-49-5
    • ~%
    • In-stock
      4-Pyrimidine methanamine|CS-W018555
      45588-79-2

    References

    • WO2008/127349 A2, ; Page/Page column 102 ; WO 2008/127349 A2
  • Route3

    References

    • Bulletin des Societes Chimiques Belges, , vol. 91, # 2 p. 153 - 162

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   -0.0647
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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