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Structure of 4837-19-8
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3-(Difluoromethoxy)benzoic acid features a para-difluoromethoxy substituent that enhances lipophilicity and metabolic stability, making it valuable for medicinal chemistry applications. The carboxylic acid group enables direct conjugation or derivatization in synthetic routes. This compound exhibits robust bench stability and compatibility with standard organic transformations under mild conditions.
3-(Difluoromethoxy)benzoic acid serves as a valuable building block in medicinal chemistry, offering a polar, electron-withdrawing difluoromethoxy group ortho to a carboxylic acid. This substitution pattern enhances metabolic stability and modulates lipophilicity, enabling direct incorporation into bioactive scaffolds. The compound exhibits good bench stability, facilitates straightforward derivatization via standard esterification or amide coupling protocols, and is compatible with common purification methods such as recrystallization.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: