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Structure of 53312-81-5
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5-Amino-2-fluorobenzonitrile features a strategically positioned amino group and fluorine atom on a benzonitrile scaffold, enabling precise tuning of electronic properties. This combination enhances solubility and reactivity in synthetic transformations, particularly in cross-coupling and cyclization reactions. The molecule’s bench-stable nature supports reliable use across diverse reaction conditions.
5-Amino-2-fluorobenzonitrile serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated heterocycles and bioactive scaffolds. Its ortho-fluoro and amino groups facilitate directed metalation and electrophilic substitution, while the nitrile group supports transformation into carboxamides or carboxylic acids. The compound exhibits good bench stability and compatibility with standard coupling reactions, making it suitable for iterative synthesis campaigns in API development.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H315-H318
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Precautionary Statements : P264-P280-P302+P352-P362
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Lot numbers can be found on the outside label of a product: