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Structure of 58164-14-0
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2-Bromo-5-(tert-butyl)aniline features a sterically hindered tert-butyl group that enhances stability and modulates reactivity. This electron-rich arylamine integrates readily into coupling reactions, offering improved solubility and handling under standard conditions.
2-Bromo-5-(tert-butyl)aniline serves as a valuable building block in medicinal chemistry and agrochemical synthesis, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The tert-butyl group provides steric protection and enhances metabolic stability, while the bromo substituent offers high reactivity in Suzuki, Stille, and Negishi couplings. Bench-stable and readily purified by column chromatography, it functions reliably in multi-step synthetic sequences requiring orthogonality and functional group tolerance.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501
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Lot numbers can be found on the outside label of a product: