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CS-W001157 4
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1H-Indazole-5-sulfonyl chloride

  • CAS No. 599183-35-4

  • Cat. No. CS-0019242
  • Molecule weightNone
  • Purity≥95%
  • MDL No.MFCD11650650

*For research and further manufacturing use only, not for direct human use.

1H-Indazole-5-sulfonyl chloride|CS-0019242

Structure of 599183-35-4

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General Information

  • CAS No. 599183-35-4
  • Cat. No. CS-0019242
  • Purity ≥95%
  • MDL No. MFCD11650650
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅ClN₂O₂S
  • Molecular Weight None
  • Synonym(s) 1H-Indazole-5-sulfonylchloride
  • SMILES O=S(C1=CC2=C(NN=C2)C=C1)(Cl)=O

Description

1H-Indazole-5-sulfonyl chloride features a reactive sulfonyl chloride group positioned at the 5-position of the indazole core, enabling direct conjugation with nucleophiles. The electron-deficient aromatic system enhances electrophilicity, facilitating efficient amide and sulfonamide formation under mild conditions. This bench-stable reagent integrates readily into complex molecule synthesis, offering precise functionalization in pharmaceutical and agrochemical development workflows.

Application

1H-Indazole-5-sulfonyl chloride serves as a versatile acylating agent for the installation of sulfonyl groups at the C5-position of indazole scaffolds. It facilitates efficient amide and sulfonamide formation under mild conditions, enabling rapid access to functionalized heterocycles relevant to medicinal chemistry. The reagent exhibits good bench stability and compatibility with common protecting groups, simplifying purification and integration into multi-step syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2923
Class : 8,6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H314-H331
Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P330+P331-P302+P352-P304+P340-P330-P361+P364-P363-P405-P501

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Computational Chemistry Data

  • TPSA   62.82
  • LogP   1.4904
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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