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CS-W001157 4
Total: USD 88.00

1H-Indazole-5-sulfonyl chloride

  • CAS No. 599183-35-4

  • Cat. No. CS-0019242
  • Purity≥95%
  • MDL No.MFCD11650650
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1H-Indazole-5-sulfonyl chloride|CS-0019242

Structure of 599183-35-4

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Description

1H-Indazole-5-sulfonyl chloride features a reactive sulfonyl chloride group positioned at the 5-position of the indazole core, enabling direct conjugation with nucleophiles. The electron-deficient aromatic system enhances electrophilicity, facilitating efficient amide and sulfonamide formation under mild conditions. This bench-stable reagent integrates readily into complex molecule synthesis, offering precise functionalization in pharmaceutical and agrochemical development workflows.

Application

1H-Indazole-5-sulfonyl chloride serves as a versatile acylating agent for the installation of sulfonyl groups at the C5-position of indazole scaffolds. It facilitates efficient amide and sulfonamide formation under mild conditions, enabling rapid access to functionalized heterocycles relevant to medicinal chemistry. The reagent exhibits good bench stability and compatibility with common protecting groups, simplifying purification and integration into multi-step syntheses.

General Information

  • CAS No. 599183-35-4
  • Cat. No. CS-0019242
  • Purity ≥95%
  • MDL No. MFCD11650650
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅ClN₂O₂S
  • Molecular Weight None
  • Synonym(s) 1H-Indazole-5-sulfonylchloride
  • SMILES O=S(C1=CC2=C(NN=C2)C=C1)(Cl)=O

Computational Chemistry Data

  • TPSA   62.82
  • LogP   1.4904
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2923
Class : 8,6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H314-H331
Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P330+P331-P302+P352-P304+P340-P330-P361+P364-P363-P405-P501

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