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CS-W001157 4
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5-(Trifluoromethyl)benzo[d]thiazol-2-amine

  • CAS No. 60388-38-7

  • Cat. No. CS-0050740
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-(Trifluoromethyl)benzo[d]thiazol-2-amine|CS-0050740

Structure of 60388-38-7

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General Information

  • CAS No. 60388-38-7
  • Cat. No. CS-0050740
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅F₃N₂S
  • Molecular Weight 218.20
  • Synonym(s) 5-Trifluoromethyl-benzothiazol-2-ylamine
  • SMILES NC1=NC2=CC(=CC=C2S1)C(F)(F)F

Description

5-(Trifluoromethyl)benzo[d]thiazol-2-amine features a trifluoromethyl group that enhances electron deficiency and metabolic stability, while the thiazole scaffold provides a rigid, planar architecture ideal for π-stacking interactions. This compound serves as a key building block in bioactive heterocycle synthesis and functional materials development.

Application

5-(Trifluoromethyl)benzo[d]thiazol-2-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds through standard coupling reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the amine functionality facilitates derivatization via amidation, alkylation, or cross-coupling. The compound exhibits good bench stability and is compatible with common reaction conditions, making it valuable for lead optimization and API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.8973
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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