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3,5-Dibromo-2-fluoro-6-methylpyridine

  • CAS No. 632628-07-0

  • Cat. No. CS-0063196
  • Molecule weight268.91
  • Purity≥98%
  • MDL No.MFCD09475419

*For research and further manufacturing use only, not for direct human use.

3,5-Dibromo-2-fluoro-6-methylpyridine|CS-0063196

Structure of 632628-07-0

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General Information

  • CAS No. 632628-07-0
  • Cat. No. CS-0063196
  • Purity ≥98%
  • MDL No. MFCD09475419
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄Br₂FN
  • Molecular Weight 268.91
  • Synonym(s) 3,5-Dromo-2-fluoro-6-methylpyridine
  • SMILES CC1=C(Br)C=C(Br)C(F)=N1

Description

3,5-Dibromo-2-fluoro-6-methylpyridine features a sterically hindered pyridine core with complementary halogenation at C3 and C5, flanked by a fluorine at C2 and a methyl group at C6. This electronic and steric profile enables selective cross-coupling reactions in late-stage functionalization workflows.

Application

3,5-Dibromo-2-fluoro-6-methylpyridine serves as a versatile building block for the synthesis of substituted pyridine derivatives. Its ortho-halogenation pattern enables palladium-catalyzed cross-coupling reactions with high regioselectivity. The fluorine and methyl groups provide enhanced stability and modulate electronic properties, facilitating downstream functionalization in medicinal chemistry and agrochemical research.

Synthesis

  • Route1

    References

    • MERCK and CO., INC. Patent: WO2003/103590 A2, 2003 ; Location in patent: Page 26-27 ; WO 03/103590 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.05412
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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