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3,3-difluorocyclobutanamine hydrochloride

  • CAS No. 637031-93-7

  • Cat. No. CS-B1074
  • Purity≥96%
  • MDL No.MFCD10001382

*For research and further manufacturing use only, not for direct human use.

3,3-difluorocyclobutanamine hydrochloride|CS-B1074

Structure of 637031-93-7

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General Information

  • CAS No. 637031-93-7
  • Cat. No. CS-B1074
  • Purity ≥96%
  • MDL No. MFCD10001382
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈ClF₂N
  • Molecular Weight 143.56
  • Synonym(s) Cyclobutanamine, 3,3-difluoro-, hydrochloride
  • SMILES NC1CC(F)(F)C1.Cl

Description

3,3-difluorocyclobutanamine hydrochloride features a strained cyclobutane core with two fluorine atoms at the 3-position, conferring enhanced metabolic stability and lipophilicity. The amine moiety is protonated as the hydrochloride salt, ensuring high solubility and ease of handling. This scaffold integrates readily into bioactive molecules for medicinal chemistry applications.

Application

3,3-Difluorocyclobutanamine hydrochloride serves as a valuable building block for fluorinated heterocycles in medicinal chemistry. The difluorocyclobutane core imparts metabolic stability and modulates lipophilicity, while the amine functionality enables straightforward derivatization via amidation, alkylation, or reductive amination. Its crystalline hydrochloride salt form ensures excellent bench stability, ease of handling, and compatibility with standard purification protocols, facilitating integration into multi-step synthetic sequences for drug discovery applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.1646
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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