4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide hydrochloride

Name: 4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide hydrochloride
Brand: ChemScene
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CAS No. 654084-41-0
Cat. No. CS-0150646
Purity≥98%
MDL No.MFCD23135408

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide hydrochloride|CS-0150646

Structure of 654084-41-0

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General Information

CAS No. 654084-41-0
Cat. No. CS-0150646
Purity ≥98%
MDL No. MFCD23135408
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₄H₂₁Cl₂N₃O₂
Molecular Weight 334.24
Synonym(s) None
SMILES COC=1C=C(C(=CC1C(=O)NCC2CCNCC2)Cl)N.Cl

Description

This hydrochloride salt features a benzamide core with strategic substituents: an electron-rich 4-amino group, a chloro at the 5-position, a methoxy at C2, and a piperidin-4-ylmethyl side chain. The protonated piperidine enhances solubility and facilitates downstream conjugation in medicinal chemistry applications.

Application

4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide hydrochloride serves as a versatile building block for medicinal chemistry campaigns, enabling the construction of substituted benzamide scaffolds via standard amide coupling and reductive amination protocols. The molecule combines a tunable aniline core with orthogonal functional groups—amine, chloro, methoxy, and piperidine—facilitating downstream diversification. Its hydrochloride salt form enhances solubility and stability, supporting efficient purification and use in high-throughput synthesis workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 76.38
LogP 2.082
H_Acceptors 4
H_Donors 3
Rotatable_Bonds 4

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide hydrochloride

CAS No. 654084-41-0

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