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CS-W001157 4
Total: USD 88.00

(4-Methyloxan-4-yl)methanamine

  • CAS No. 65626-24-6

  • Cat. No. CS-0053196
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(4-Methyloxan-4-yl)methanamine|CS-0053196

Structure of 65626-24-6

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General Information

  • CAS No. 65626-24-6
  • Cat. No. CS-0053196
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₅NO
  • Molecular Weight 129.20
  • Synonym(s) 4-AMinoMethyl-4-Methyltetrahydro-2H-pyran
  • SMILES CC1(CN)CCOCC1

Description

This bench-stable amine features a cyclic ether scaffold that enhances solubility and stability in polar solvents. The pendant primary amine enables straightforward functionalization, while the methyl group provides steric modulation. Ideal for synthesizing bioactive molecules and polymer linkers under standard conditions.

Application

(4-Methyloxan-4-yl)methanamine serves as a versatile building block in medicinal chemistry, enabling the construction of saturated heterocyclic scaffolds with defined stereochemistry. Its tertiary amine functionality and pendant methylene group facilitate efficient derivatization via alkylation, reductive amination, or incorporation into macrocyclic frameworks. The oxane ring imparts favorable solubility and metabolic stability, while the bench-stable nature simplifies handling and purification in multi-step syntheses.

Synthesis

  • Route1

    References

    • NOVARTIS AG; PFISTER, Keith B; SENDZIK, Martin Patent: WO2011/26917 A1, 2011 ; Location in patent: Page/Page column 63 ; WO 2011/026917 A1
  • Route2

    References

    • NOVARTIS AG; PFISTER, Keith B; SENDZIK, Martin Patent: WO2011/26917 A1, 2011 ; WO 2011/026917 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   0.7618
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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