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CS-W001157 4
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4-Methyl-1,3-thiazol-5-amine

  • CAS No. 72632-65-6

  • Cat. No. CS-0057969
  • Molecule weight114.17
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Methyl-1,3-thiazol-5-amine|CS-0057969

Structure of 72632-65-6

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General Information

  • CAS No. 72632-65-6
  • Cat. No. CS-0057969
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₆N₂S
  • Molecular Weight 114.17
  • Synonym(s) 5-Amino-4-methylthiazole
  • SMILES NC1=C(C)N=CS1

Description

4-Methyl-1,3-thiazol-5-amine features a thiazole core with a methyl group at the 4-position and a primary amine at the 5-position. This electron-rich heterocycle integrates readily into medicinal chemistry scaffolds, offering enhanced solubility and metabolic stability in bioactive molecule design.

Application

4-Methyl-1,3-thiazol-5-amine serves as a versatile heterocyclic building block in medicinal chemistry and synthetic organic research. Its thiazole core provides robust stability and favorable electronic properties, while the pendant amine enables facile derivatization via amidation, alkylation, or coupling reactions. The methyl group enhances lipophilicity and metabolic stability, making it valuable for constructing bioactive scaffolds. Bench-stable and readily purified by standard methods, it functions effectively in diverse reaction conditions.

Synthesis

  • Route1
    • 2-Methylpropanedinitrile|CS-0263861
      3696-36-4
    • ~%
    • In-stock
      4-Methyl-1,3-thiazol-5-amine|CS-0057969
      72632-65-6

    References

    • Schoellkopf,U.; Hantke,K. Liebigs Annalen der Chemie, 1979 , p. 1602 - 1605

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.03372
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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