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CS-W001157 4
Total: USD 88.00

5-Chloro-[1,1'-biphenyl]-2-amine

  • CAS No. 73006-78-7

  • Cat. No. CS-0132138
  • Molecule weight203.67
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Chloro-[1,1'-biphenyl]-2-amine|CS-0132138

Structure of 73006-78-7

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General Information

  • CAS No. 73006-78-7
  • Cat. No. CS-0132138
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₀ClN
  • Molecular Weight 203.67
  • Synonym(s) 5-chloro-biphenyl-2-ylamine
  • SMILES NC1=CC=C(Cl)C=C1C2=CC=CC=C2

Description

Tazobactam is a drug is used in conjunction with beta-lactamase susceptible penicillins to treat infections caused by beta-lactamase producing organisms. It acts as a beta lactamase inhibitor. It is used in combination with piperacillin to broaden the spectrum of piperacillin antibacterial action. It is used as antibiotic in the treatment of nosocomial pneumonia caused by Pseudomonas aeruginosa.

Application

5-Chloro-[1,1'-biphenyl]-2-amine serves as a versatile building block in medicinal chemistry and materials science, enabling efficient Suzuki-Miyaura and Buchwald-Hartwig couplings. Its ortho-chloro and aniline functionalities provide complementary reactivity for sequential functionalization. The compound exhibits excellent bench stability, facilitates straightforward purification via recrystallization, and functions as a key scaffold in the synthesis of biologically active heterocycles and advanced organic semiconductors.

Synthesis

  • Route1

    References

    • ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2006/37982 A2, 2006 ; Location in patent: Page/Page column 23 ; WO 2006/037982 A2
  • Route2

    References

    • Xie, Jin; Yuan, Xiangai; Abdukader, Ablimit; Zhu, Chengjian; Ma, Jing Organic Letters, 2014 , vol. 16, # 6 p. 1768 - 1771
  • Route3
    • In-stock
      Phenyl trifluoromethanesulfonate|CS-0121626
      17763-67-6
    • null|null
      106-47-8
    • ~60%
    • In-stock
      5-Chloro-[1,1'-biphenyl]-2-amine|CS-0132138
      73006-78-7

    References

    • Truong, Thanh; Daugulis, Olafs Organic Letters, 2012 , vol. 14, # 23 p. 5964 - 5967

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   3.5892
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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