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Structure of 78197-27-0
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4-Fluoropiperidine delivers a strategically positioned fluorine atom that enhances metabolic stability and modulates basicity within medicinal chemistry scaffolds. This bench-stable, moisture-tolerant heterocycle integrates readily into bioactive molecules, offering improved membrane permeability and targeted pharmacokinetic profiles in drug discovery campaigns.
4-Fluoropiperidine serves as a valuable building block in medicinal chemistry, enabling the introduction of a fluorinated alkylamine moiety with enhanced metabolic stability and improved membrane permeability. Its well-established reactivity facilitates nucleophilic substitution, amide coupling, and transition-metal-catalyzed transformations. The compound exhibits favorable bench stability and compatibility with common protecting group strategies, making it ideal for modular synthesis of bioactive heterocycles and API intermediates.
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GHS Pictogram :
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GHS No : GHS02,GHS05
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Signal Word : Danger
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UN#: 2920
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Class : 8,3
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Packing Group : Ⅱ
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Hazard Statements : H226-H314
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P264-P280-P301+P330+P331-P304+P340-P363-P370+P378-P405-P501
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Lot numbers can be found on the outside label of a product: