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CS-W001157 4
Total: USD 88.00

3,4-Dimethylpyridin-2-amine

  • CAS No. 823-39-2

  • Cat. No. CS-0061162
  • Purity≥98%
  • MDL No.MFCD02247162

*For research and further manufacturing use only, not for direct human use.

3,4-Dimethylpyridin-2-amine|CS-0061162

Structure of 823-39-2

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General Information

  • CAS No. 823-39-2
  • Cat. No. CS-0061162
  • Purity ≥98%
  • MDL No. MFCD02247162
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀N₂
  • Molecular Weight 122.17
  • Synonym(s) 3,4-Dimethyl-2-pyridinamine
  • SMILES CC1=C(C)C(=N)NC=C1

Description

3,4-Dimethylpyridin-2-amine features a pyridine core with methyl groups at the 3- and 4-positions, enhancing electron density at the nitrogen lone pair. This configuration supports strong coordination in catalytic systems and improves solubility in organic solvents. The compound serves as a robust ligand in transition metal catalysis and integrates readily into complex molecular architectures.

Application

3,4-Dimethylpyridin-2-amine serves as a versatile building block in medicinal chemistry and catalysis, offering enhanced solubility and stability compared to unsubstituted pyridine derivatives. The ortho-dimethyl substitution pattern facilitates directed metalation and enables selective functionalization at the 2-position. Its nitrogen lone pair supports coordination in transition-metal complexes, while the methyl groups provide steric protection and improved metabolic stability in bioactive scaffolds.

Synthesis

  • Route1
    • null|null
      1233519-99-7
    • ~%
    • In-stock
      3,4-Dimethylpyridin-2-amine|CS-0061162
      823-39-2

    References

    • WO2010/72722 A1, ; Page/Page column 31 ; WO 2010/072722 A1
  • Route2
    • null|null
      583-58-4
    • ~%
    • In-stock
      4,5-Dimethylpyridin-2-amine|CS-0153165
      57963-11-8
    • In-stock
      3,4-Dimethylpyridin-2-amine|CS-0061162
      823-39-2

    References

    • Journal of Heterocyclic Chemistry, , vol. 18, p. 1613 - 1618
  • Route3
    • null|null
      583-58-4
    • null|null
      121-69-7
    • ~%
    • In-stock
      4,5-Dimethylpyridin-2-amine|CS-0153165
      57963-11-8
    • In-stock
      3,4-Dimethylpyridin-2-amine|CS-0061162
      823-39-2

    References

    • US5972975 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301+H311+H331-H373
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.28064
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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