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Structure of 827614-70-0
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This boronate ester features a trifluorophenyl group conjugated to a stable dioxaborolane core, enabling efficient cross-coupling under mild conditions. The tetramethyl substitution enhances shelf stability and solubility in organic media, while the electron-deficient aryl moiety facilitates rapid transmetalation. Ideal for Suzuki-Miyaura reactions requiring high functional group tolerance and predictable reactivity.
4,4,5,5-Tetramethyl-2-(3,4,5-trifluorophenyl)-1,3,2-dioxaborolane serves as a stable, bench-ready boron building block for Suzuki-Miyaura cross-coupling reactions. Its trifluorophenyl moiety enables efficient coupling with aryl and heteroaryl halides, offering enhanced electron-withdrawing character for improved reactivity in challenging transformations. The tetramethyl substitution ensures high stability, minimal protodeboronation, and ease of purification, making it ideal for constructing complex pharmaceutical scaffolds and functionalized biaryls in iterative synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: