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2,8-Diazaspiro[4.5]decan-1-one hydrochloride

  • CAS No. 832710-65-3

  • Cat. No. CS-B1272
  • Molecule weight190.67
  • Purity≥97%
  • MDL No.MFCD02179151

*For research and further manufacturing use only, not for direct human use.

2,8-Diazaspiro[4.5]decan-1-one hydrochloride|CS-B1272

Structure of 832710-65-3

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General Information

  • CAS No. 832710-65-3
  • Cat. No. CS-B1272
  • Purity ≥97%
  • MDL No. MFCD02179151
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₅ClN₂O
  • Molecular Weight 190.67
  • Synonym(s) 2,8-diazaspiro[4.5]decan-1-one,hydrochloride
  • SMILES O=C1C2(CCNCC2)CCN1.Cl

Description

2,8-Diazaspiro[4.5]decan-1-one hydrochloride features a rigid spirocyclic scaffold with strategically positioned nitrogen atoms, enabling precise stereocontrol in asymmetric synthesis. The protonated amine enhances solubility and facilitates salt formation, improving handling and stability under standard bench conditions. This configuration supports efficient incorporation into complex molecular architectures.

Application

2,8-Diazaspiro[4.5]decan-1-one hydrochloride serves as a versatile scaffold in medicinal chemistry, enabling the construction of constrained heterocyclic systems. Its spirocyclic architecture provides rigidity to optimize target binding affinity, while the ketone and amine functionalities offer sites for derivatization. The hydrochloride salt enhances solubility and stability, facilitating handling and purification in standard synthetic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   41.13
  • LogP   0.2979
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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