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Structure of 849751-48-0
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tert-Butyl (2-chloropyrimidin-4-yl)carbamate delivers a protected pyrimidine amine scaffold with enhanced stability and solubility. The chloropyrimidine moiety enables direct functionalization, while the tert-butyl carbamate group facilitates selective deprotection under mild acidic conditions. This compound integrates seamlessly into medicinal chemistry campaigns requiring late-stage diversification.
tert-Butyl (2-chloropyrimidin-4-yl)carbamate serves as a versatile building block in medicinal chemistry, enabling efficient introduction of a chloropyrimidine moiety with orthogonal protection. The carbamate group provides bench stability and facilitates selective deprotection under mild acidic conditions. It reacts readily in palladium-catalyzed cross-coupling reactions, particularly Suzuki-Miyaura and Buchwald-Hartwig aminations, making it ideal for constructing functionalized pyrimidine scaffolds commonly found in kinase inhibitors and antiviral agents.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: