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CS-W001157 4
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N-Methyl-1-(o-tolyl)methanamine

  • CAS No. 874-33-9

  • Cat. No. CS-0045339
  • Purity≥96%
  • MDL No.None
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

N-Methyl-1-(o-tolyl)methanamine|CS-0045339

Structure of 874-33-9

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Description

N-Methyl-1-(o-tolyl)methanamine is a bench-stable, moisture-tolerant amine featuring a methylated nitrogen adjacent to a benzene ring substituted with a methyl group at the ortho position. This structure imparts enhanced electron density and steric bulk, enabling efficient coupling in pharmaceutical synthesis and facilitating selective functionalization in complex molecular scaffolds.

Application

N-Methyl-1-(o-tolyl)methanamine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive amine scaffolds through standard functional group transformations. Its ortho-substituted aromatic core provides steric and electronic modulation, while the tertiary amine functionality offers favorable solubility and metabolic stability. The compound exhibits bench stability and compatibility with common coupling and reduction protocols, facilitating efficient synthesis of target molecules in drug discovery workflows.

General Information

  • CAS No. 874-33-9
  • Cat. No. CS-0045339
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₃N
  • Molecular Weight 135.21
  • Synonym(s) N-methyl(2-methylphenyl)methanaminium
  • SMILES CC1=CC=CC=C1CNC

Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.71442
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314-H318
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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