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Structure of 874-33-9
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N-Methyl-1-(o-tolyl)methanamine is a bench-stable, moisture-tolerant amine featuring a methylated nitrogen adjacent to a benzene ring substituted with a methyl group at the ortho position. This structure imparts enhanced electron density and steric bulk, enabling efficient coupling in pharmaceutical synthesis and facilitating selective functionalization in complex molecular scaffolds.
N-Methyl-1-(o-tolyl)methanamine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive amine scaffolds through standard functional group transformations. Its ortho-substituted aromatic core provides steric and electronic modulation, while the tertiary amine functionality offers favorable solubility and metabolic stability. The compound exhibits bench stability and compatibility with common coupling and reduction protocols, facilitating efficient synthesis of target molecules in drug discovery workflows.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 2735
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H314-H318
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: