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6-Chloro-2-methylpyridine-3-sulfonyl chloride

  • CAS No. 889944-74-5

  • Cat. No. CS-0209726
  • Purity≥95%
  • MDL No.MFCD08436477

*For research and further manufacturing use only, not for direct human use.

6-Chloro-2-methylpyridine-3-sulfonyl chloride|CS-0209726

Structure of 889944-74-5

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General Information

  • CAS No. 889944-74-5
  • Cat. No. CS-0209726
  • Purity ≥95%
  • MDL No. MFCD08436477
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅Cl₂NO₂S
  • Molecular Weight 226.08
  • Synonym(s) None
  • SMILES CC1=NC(=CC=C1S(=O)(=O)Cl)Cl

Description

6-Chloro-2-methylpyridine-3-sulfonyl chloride features a sulfonyl chloride group flanked by electron-withdrawing chlorine and methyl substituents, enabling selective acylation in heterocyclic synthesis. This bench-stable reagent integrates efficiently into pharmaceutical intermediates and functionalized materials, offering high reactivity under mild conditions with minimal side reactions.

Application

6-Chloro-2-methylpyridine-3-sulfonyl chloride serves as a versatile sulfonyl chloride building block for the synthesis of sulfonamide-containing compounds. Its reactivity enables efficient coupling with amines under mild conditions, facilitating rapid access to functionalized pyridine derivatives. The chloro and methyl substituents provide orthogonal handles for further derivatization, while the sulfonyl chloride group offers excellent bench stability and ease of purification, making it well-suited for high-throughput medicinal chemistry campaigns and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   47.03
  • LogP   1.97092
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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