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CS-W001157 4
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3-Bromo-6-chloropyridine-2-carboxylic acid

  • CAS No. 929000-66-8

  • Cat. No. CS-W005193
  • Purity≥95%
  • MDL No.MFCD09258777
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Bromo-6-chloropyridine-2-carboxylic acid|CS-W005193

Structure of 929000-66-8

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Description

3-Bromo-6-chloropyridine-2-carboxylic acid features a pyridine core functionalized with bromo, chloro, and carboxylic acid groups at strategic positions, enabling direct incorporation into cross-coupling and bioconjugation workflows. The electron-deficient ring enhances reactivity in palladium-catalyzed transformations, while the carboxylic acid facilitates derivatization or salt formation for improved solubility and handling.

Application

3-Bromo-6-chloropyridine-2-carboxylic acid serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen functionality. The carboxylic acid group facilitates direct derivatization or activation for amide bond formation, while the bromo and chloro substituents provide complementary reactivity for sequential functionalization. Its bench-stable crystalline form supports straightforward handling and purification, making it well-suited for medicinal chemistry and process development workflows.

General Information

  • CAS No. 929000-66-8
  • Cat. No. CS-W005193
  • Purity ≥95%
  • MDL No. MFCD09258777
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrClNO₂
  • Molecular Weight 236.45
  • Synonym(s) 3-bromo-6-chloro-pyridine-2-carboxylic acid
  • SMILES O=C(C1=NC(Cl)=CC=C1Br)O

Computational Chemistry Data

  • TPSA   50.19
  • LogP   2.1957
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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