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CS-W001157 4
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4-Amino-3,5-dichloro-6-fluoropyridin-2(1H)-one

  • CAS No. 94133-62-7

  • Cat. No. CS-0132536
  • Purity≥98%
  • MDL No.MFCD09751333

*For research and further manufacturing use only, not for direct human use.

4-Amino-3,5-dichloro-6-fluoropyridin-2(1H)-one|CS-0132536

Structure of 94133-62-7

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General Information

  • CAS No. 94133-62-7
  • Cat. No. CS-0132536
  • Purity ≥98%
  • MDL No. MFCD09751333
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃Cl₂FN₂O
  • Molecular Weight 196.99
  • Synonym(s) 4-Amino-3,5-dichloro-6-fluoro-2-pyridone
  • SMILES FC(N1)=C(Cl)C(N)=C(Cl)C1=O

Description

4-Amino-3,5-dichloro-6-fluoropyridin-2(1H)-one features a highly electron-deficient pyridinone core with orthogonal functional groups enabling direct incorporation into pharmaceutical scaffolds. The amino group supports facile derivatization, while the dichloro and fluoro substituents enhance metabolic stability and modulate electronic properties. This compound serves as a key intermediate in the synthesis of kinase inhibitors and bioactive heterocycles.

Application

4-Amino-3,5-dichloro-6-fluoropyridin-2(1H)-one serves as a versatile building block for heterocyclic synthesis, enabling efficient access to pyridone-based scaffolds. Its complementary electron-withdrawing substituents facilitate nucleophilic substitution and transition-metal-catalyzed coupling reactions. The molecule exhibits bench stability, moderate solubility, and compatibility with standard purification methods, making it well-suited for medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   58.88
  • LogP   1.403
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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